ranolazine is a new antianginal drug that is postulated to act through blocking of cardiac late sodium channels and improvement in cardiac blood flow. the present study has been carried out to investigate its possible effect on microcirculation of normal and diabetic rats’ cardiac muscle. methods: normal and diabetic rats were anesthetized. the chest was opened and a surface laser doppler flowm...

Background: Alprostadil can effectively dilate blood vessels, improve cardiac microcirculation, and reduce load. Tanshinone IIa injection protect against atherosclerosis myocardial oxygen consumption. However, the effects of alprostadil combined with tanshinone on microcirculation disorder, outcomes, function in patients acute infarction (AMI) after percutaneous coronary intervention (PCI) are ...

The coronary microcirculation is a key determinant of blood supply to the myocardium and outweighs epicardial arteries in its abundance distribution. Recent studies have shown clinical benefit assessing microcirculation, this practice has now been given recommendation within latest international guidelines consensus statements. However, uptake remains low. We continue focus our efforts diagnosi...

BACKGROUND The aim of this study was to establish a new experimental model to directly analyse the coronary microcirculation in cardiac xenografts. METHODS Intravital fluorescence microscopy (IVM) of the subepicardial microcirculation in heterotopically transplanted hamster-to-rat cardiac xenografts was performed at 30 and 90 min of reperfusion. We quantitatively assessed the microcirculatory...

BACKGROUND It is not clear whether moderate intraoperative blood loss and norepinephrine used to restore the macrocirculation impair microcirculation affect microcirculation/macrocirculation coherence. OBJECTIVE We sought investigate effect of therapy administered treat hypotension on sublingual microcirculation. DESIGN Prospective observational study. SETTING University Medical Center Hamburg-...

BACKGROUND This study was performed to compare intestinal and sublingual microcirculation and their response to a fluid challenge. METHODS Twenty-two septic patients in the first postoperative day of an intestinal surgery, in which an ostomy had been constructed, were evaluated both before and 20 min after a challenge of 10 mL/kg of 6% hydroxyethylstarch 130/0.4. We measured systemic hemodyna...

Red cell distribution width (RDW) is a simple, inexpensive, and unique laboratory parameter. This hematologic parameter reflecting the heterogeneity of red size was used conventionally to differentiate anemic diseases but currently as prognostic marker common well cardiac diseases. Higher RDW associated with lower therapeutic response in patients acute myocardial infarction undergoing percutane...

BACKGROUND This research describes an early preclinical study of the biophysical mechanisms governing changes in myocardial T2 during vasodilation in normal myocardium. METHODS AND RESULTS Theoretical modeling and experimental studies in an instrumented pig model (n=7) provided measures of changes in myocardial T2, relative blood volume (BV), and microcirculation oxygen levels (%O2) during in...

Cardiac surgery with cardiopulmonary bypass and cardioplegic arrest is associated with injury to the vasculature and microcirculation leading to coronary microvascular dysfunction, permeability changes and cardiac dysfunction. In the setting of cardiopulmonary bypass with cardioplegia, poorly-controlled diabetes is associated with significant changes in endothelium-dependent and independent vas...

Age-related changes in skin contribute to impaired wound healing after surgical procedures. Changes in skin with age include decline in thickness and composition, a decrease in the number of most cell types, and diminished microcirculation. The microcirculation provides tissue perfusion, fluid homeostasis, and delivery of oxygen and other nutrients. It also controls temperature and the inflamma...